Editorial focus: entering into the non-coding RNA era
نویسندگان
چکیده
منابع مشابه
Editorial for "non-coding RNA methods".
The bright future of (non-coding) RNAs: methods light the way The human genome project took 13 years and $1/base pair for a total of $3 billion to complete [1]. When the entire sequence became available a decade ago, the hope was that a complete understanding of how a human cell lives and dies would soon follow. Instead, we learned that the number of protein-coding genes is much smaller than pr...
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Up to 90% of eukaryotic genomes are transcribed. Only ~ 2% of these transcripts encode proteins, while remaining 98% are ncRNAs [1,2]. ncRNAs can be categorized into infrastructural ncRNAs and regulatory ncRNAs. Constitutively expressed infrastructural ncRNAs include ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs). Based on their si...
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Summary: SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA associated with cancer pathogenesis. It contributes to a variety of cellular functions and recent evidence propounds its association with autophagy process. It has been showed that SOX2OT can regulate the expression of different autophagy associated factors in human cells with different mechanisms, however more remains to ...
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The Iranian Rehabilitation Journal (IRJ) invites research papers on the genetic basis of single gene and complex disorders. This vastly dynamic branch of science will complement the multidisciplinary wealth of expertise in the fields of social welfare and rehabilitation. The past few years have witnessed outstanding research projects on the genetic causes of numerous debilitating disorders, suc...
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Our understanding of the functions that non-coding RNAs play in shaping the immune response is still in its infancy. The breakthroughs in deep sequencing technology have provided us with an unprecedented view of the human genome. The deeper we sequence the more non-coding genes we identify, while the number of protein coding genes remains constant. GENCODE represents the gene set of the ENCODE ...
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ژورنال
عنوان ژورنال: Cellular & Molecular Biology Letters
سال: 2018
ISSN: 1425-8153,1689-1392
DOI: 10.1186/s11658-018-0111-3